Mizoribine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种免疫抑制剂，通过抑制 IMPDH 选择性抑制淋巴细胞增殖。类风湿性关节炎已批准

An immunosuppressive agent that inhibits the proliferation of lymphocytes selectively, via inhibition of IMPDH.Rheumatoid Arthritis Approved(In Vitro):Mizoribine, isolated from culture medium of the mold Eupenicillium brefeldianum M-2166, acts as an immunosuppressant which exerts its effects without severe side effects.Mizoribine is an inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitorused for renal transplantation, autoimmune diseases and steroid-resistant nephrotic syndrome .(In Vivo):Mizoribine suppresses collagen-induced arthritis. Mizoribine (10, 20 and 50 mg/kg; Administered orally 5 days a week for 12 weeks) reduces the arthritis score in a dose-dependent fashion, showing significant suppression, even at a dose of 10 mg/kg.

Mizoribine, isolated from culture medium of the mold Eupenicillium brefeldianum M-2166, acts as an immunosuppressant which exerts its effects without severe side effects.Mizoribine is an inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitorused for renal transplantation, autoimmune diseases and steroid-resistant nephrotic syndrome .

Mizoribine suppresses collagen-induced arthritis. Mizoribine (10, 20 and 50 mg/kg; Administered orally 5 days a week for 12 weeks) reduces the arthritis score in a dose-dependent fashion, showing significant suppression, even at a dose of 10 mg/kg. Animal Model:Male DBA/1 J mice with collagen-induced arthritisDosage:10, 20 and 50 mg/kg Administration:Administered orally 5 days a week for 12 weeks Result:Showed dose-dependency of the suppressive effect.

NSC-289637 | HE-69

Others

Other Targets

monophosphatesynthetase

Inflammation/Immunology

Rheumatoid Arthritis

50924-49-7

259.216

C9H13N3O6

>98% (HPLC)

DMSO: ≥ 35 mg/mL

O=C(C1=C(O)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=N1)N

1H-Imidazole-4-carboxamide, 5-hydroxy-1-β-D-ribofuranosyl-

(-20℃)

With Ice Pack

≥ 2 years