L-Mimosine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L-Mimosine 是一种非蛋白质氨基酸，可作为铁螯合剂。

L-Mimosine is a non-protein amino acid, and acts as an iron chelator.

Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore. Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena.Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa.Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells.Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment.

Mimosine (30, and 60 mg/kg) decreases sperm concentration. Animal Model:ICR male mice (6-8 weeks)Dosage:15, 30, or 60 mg/kg Administration:Injected (i.p.) for 7 consecutive days Result:Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg.

Leucenol | NSC 69188

Others

Other Targets

Others

Other Indications

——

500-44-7

198.18

C8H10N2O4

>98% (HPLC)

DMSO:0.01 mg/mL (0.05 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

O=C(O)[C@@](N)(N(C=C1)C=CC1=O)CO

(S)-alpha-Amino-3-hydroxy-4-oxo-1(4H)-pyridylpropionic acid

(-20℃)

With Ice Pack

≥ 2 years