MMRi64

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MMRi64 是一种小分子抑制剂，可在体外破坏 Mdm2-MdmX RING-RING 相互作用并激活癌细胞中的 p53。

MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a.

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MMRi64

Apoptosis

MDM2-p53

MDM2-p53

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430458-66-5

410.298

C22H17Cl2N3O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (243.72 mM)

OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(Cl)=C3Cl)NC4=NC=CC(C)=C4

7-[(2,3-Dichlorophenyl)[(4-methyl-2-pyridinyl)amino]methyl]-8-quinolinol

(-20℃)

With Ice Pack

≥ 2 years