YM-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YM-1 是 MTK-077 的紧密衍生物，以变构方式促进 Hsp70 与未折叠底物的结合，与 Hsp70 特异性结合，Kd 为 4.9 uM。

YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM; enhances client protein ubiquitination and polyQ AR degradation; alleviates toxicity in a Drosophila model of spinobulbar muscular atrophy (SBMA); also disrupts the Hsp70-Bag3 interaction with IC50 of 5 uM.

Western Blot Analysis Cell Line:HeLa and hTERT-RPE1 cell lines Concentration:10 μM Incubation Time:48 hoursI Result:Increased the level of p53 and p21 and decreased the level of FoxM1 and survivin.

Animal Model:UAS-hAR52Q flies with polyQ AR-induced dihydrotestosterone (DHT) phenotypeDosage:1 mM Administration:Oral administration; 1 mM, for 7 days Result:Weakened the DHT-dependent eye degeneration phenotype and rescued DHT-dependent pupal toxicity of the polyQ AR.

YM1

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP

——

——

409086-68-6

417.97

C20H20ClN3OS2

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (119.62 mM)

CCN1C(=CC2=CC=CC=[N+]2C)SC(=C3N(C4=CC=CC=C4S3)C)C1=O.[Cl-]

2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride

(-20℃)

With Ice Pack

≥ 2 years