PHA-680632

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的、高选择性的 Aurora 激酶抑制剂，对 Aurora A、B 和 C 的 IC50 值分别为 27、135 和 120 nM。

A potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively; exhibits at least 30- to 200-fold selectivity against a panel of 22 kinases compared with Aurora A; has potent antiproliferative activity in a wide range of cancer cell types (IC50=0.06-7.15 uM); shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.

——

——

PHA680632 | PHA 680632

Cell Cycle/DNA Damage

Aurora Kinase

Aurora A| Aurora B| Aurora C| FGFR1| PLK1

Cancer

——

398493-79-3

501.6232

C28H35N7O2

>98% (HPLC)

DMSO: ≥ 30 mg/mL

O=C(N(C1)CC2=C1C(NC(C3=CC=C(N4CCN(C)CC4)C=C3)=O)=NN2)NC5=C(CC)C=CC=C5CC

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-

(-20℃)

With Ice Pack

≥ 2 years