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A-317567
CAS No. 371217-32-2
A-317567 ( A317567 )
产品货号. M14278 CAS No. 371217-32-2
A-317567 (A317567) 是一种新型强效酸传感离子通道 (ASIC) 阻断剂，IC50 为 2-30 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3021 | 有现货 |
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| 50MG | ￥17091 | 有现货 |
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| 100MG | ￥25515 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称A-317567
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A-317567 (A317567) 是一种新型强效酸传感离子通道 (ASIC) 阻断剂，IC50 为 2-30 uM。
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产品描述A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM; inhibits pH 4.5-evoked ASIC currents, also equipotently blocks the sustained phase of ASIC3-like current; is more potent than amiloride in vitro and in vivo pain models, with minimal brain penetration.Pain Discontinued.
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体外实验——
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体内实验Animal Model:Adult male Sprague-Dawley rats (230-350 g) injected with Complete Freund’s Adjuvant- (CFA-) induced thermal hyperalgesia.Dosage:1-100 μmol/kg Administration:i.p; once Result:Showed dose-dependent analgesic effects.
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同义词A317567
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通路Membrane Transporter/Ion Channel
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靶点Sodium Channel
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受体Sodium Channel
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研究领域Neurological Disease
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适应症Pain
化学信息
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CAS Number371217-32-2
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分子量397.566
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分子式C27H31N3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESN=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N
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化学全称6-{2-[2-methyl-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]cyclopropyl}naphthalene-2-carboximidamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Silperisone HCl
Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells, decreases excitability and contractility of muscle cells, reduces peripheral tone, and acts as a muscle relaxant and peripheral vasodilator. Silperisone HCl is used to treat recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, dystonia symptoms, cone tension syndrome, multiple sclerosis myospasm and myelitis. silperisone is a sodium channel protein type 2 alpha channel blocker. silperisone is an organosilicon similar to tolperisone, an organosilicon compound with centrally acting muscle relaxant properties.
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Nav1.8-IN-4
Nav1.8-IN-4 (化合物 9a) 是一种 Nav1.8 通道抑制剂 (IC50=0.014 μM)。Nav1.8-IN-4 可用于疼痛相关疾病的研究。
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Lacosamide
一种抗惊厥化合物，可增强电压门控钠通道的缓慢失活，而不影响电压门控钠通道的快速失活。
