UBCS039

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UBCS039 (UBCS-039) 是 NAD+ 依赖性蛋白赖氨酸脱乙酰酶 SIRT6 的第一个合成激活剂，EC50 为 38 uM。

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM; shows robust activating effects on Sirt6-dependent H3K18ac deacetylation of full-length histone proteins and complete HeLa nucleosomes, with no statistically significant effects on basal Sirt1, 2, and 3 deacetylation activities; induces autophagosome accumulation and promotes autophagic flux in human cancer cells, triggers ROS accumulation and activates the AMPK/ULK1 signaling pathway.

Western Blot Analysis Cell Line:Human H1299 cells.Concentration:75 μM.Incubation Time:48 and 72 hours.Result:Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.Western Blot Analysis Cell Line:Human H1299 cells.Concentration:75 μM.Incubation Time:48 and 72 hours.Result:Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.Cell Proliferation Assay Cell Line:Human H1299 cells.Concentration:100 μM.Incubation Time:48 and 72 hours.Result:Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.

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UBCS-039 | UBCS 039

Chromatin/Epigenetic

Sirtuin

Sirtuin

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358721-70-7

247.301

C16H13N3

>98% (HPLC)

DMSO : 125 mg/mL 505.48 mM

N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1

4-(pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

(-20℃)

With Ice Pack

≥ 2 years