N.41

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N.41（HIV抑制剂N.41、Vif抑制剂N.41）是一种新型HIV-1抑制剂，针对人APOBEC3G（A3G）蛋白的Vif依赖性降解（IC50=2.2 uM）。

N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM); shows potent antiviral activity in A3G(+) but not in A3G(-) T cells with IC50 of 8.4 uM and TC50 of >100 uM against HIV-1Ba-L replication in peripheral blood mononuclear cells; inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner.

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HIV inhibitor N.41 | Vif inhibitor N.41

Microbiology/Virology

HIV

HIV

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357441-99-7

254.289

C15H14N2O2

>98% (HPLC)

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C/C(NC1=CC=C(O)C=C1)=C/C(C2=CC=CN=C2)=O

3-((4-hydroxyphenyl)amino)-1-(pyridin-3-yl)but-2-en-1-one

(-20℃)

With Ice Pack

≥ 2 years