Pikamilone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Picamilon 是一种具有口服活性的 γ-氨基丁酸的衍生物，具有益智作用。Picamilon 能够改善大鼠癫痫模型，并促进 Alloxan (HY-W017227) 诱导的大鼠糖尿病模型的胰腺功能紊乱的矫正。

Pikamilone is an intelligent medicine.

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Animal Model:Picrotoxin (HY-101391)-induced epilepsy model in rats Dosage:20 or 50 mg/kgAdministration:Intraperitoneal injection (i.p.)Result:Significantly decreased the frequency and duration of seizure spike-wave discharges (SWDs) in doses of 50 mg/kg. Decreased the intensity of SWDs in smaller doses (20 mg/kg).Animal Model:Alloxan (HY-W017227)-induced diabetes mellitus model in rats Dosage:250 mg/ kg Administration:Oral gavage (p.o.)Result:Suppressed NLRP3 activity, as indicated by a significant decrease in the area of immunopositive pancreatocytes to (21,30 ± 5,44) and (39,31 ± 5,24) %, respectively, relative to the value in the group of animals that were not treated (75,19±7,69%).Promoted correction of functional disorders of the pancreas during alloxan-induced diabetes mellitus by inhibiting activation of NLRP3 inflammasome in pancreatocytes.

Nicotinoyl-GABA | Nicotinoyl GABA | NicotinoylGABA | Pikamilon | Pikamilone

Others

Other Targets

Others

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34562-97-5

208.21

C10H12N2O3

>98% (HPLC)

Soluble in DMSO

O=C(O)CCCNC(C1=CN=CC=C1)=O

4-(nicotinamido)butanoic acid

(-20℃)

With Ice Pack

≥ 2 years