Col 003

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Col 003 是一种小分子化合物，可抑制 Hsp47 与胶原蛋白的相互作用，IC50 为 1.8 uM。

Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47; competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.

Western Blot Analysis Cell Line:Wild-type MEFs Concentration:100 μM Incubation Time:After 50 °C or 37 °C for 15 min Result:Affected correctly folded triple helix structures and α,α′-dipyridyl on collagen secretion.

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Col003

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP

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328565-16-8

257.245

C14H11NO4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (194.37 mM)

C1=CC=C(C=C1)CC2=CC(=C(C(=C2)[N+](=O)[O-])O)C=O

5-benzyl-2-hydroxy-3-nitrobenzaldehyde

(-20℃)

With Ice Pack

≥ 2 years