Mesoridazine Besylate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mesoridazine (TPS-23) benzenesulfonate 是硫唑嗪的活性代谢物，是一种具有口服的活性吩噻嗪类抗精神类疾病试剂。Mesoridazine benzenesulfonate 是一种有效、快速的人类醚-a-go-go 相关基因 (hERG) 通道的阻断剂，在 0 mV 时阻断人胚肾 293 细胞 hERG 电流的 IC50 为 550 nM。Mesoridazine benzenesulfonate 可用于精神分裂症以及某些其他精神疾病的研究。

Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The drug's name is derived from the methylsulfoxy and piperidine functional groups in its chemical structure.

Mesoridazine blocks human ether-a-go-go-related gene (HERG) currents in a concentration-dependent manner (IC50 = 550 nM at 0 mV), block increased significantly over the voltage range where HERG activates and saturates at voltages eliciting maximal HERG channel activation.Mesoridazine (15 mM; 24 h) shows total absorption of 15.94 ± 4.04% and 39.24 ± 5.11% in nude mouse and pig skin, respectively.

Mesoridazine (15 mM; topical administration; once or daily for 7 consecutive days) displays potent activity and a long period of analgesia at blocking cutaneous pain.Mesoridazine (15 mM) shows intradermal concentration of 0.34 0.74 nmol/mg after topical application on nude mouse back for 6 h. Animal Model:Eight-week-old female nude mice Dosage:15 mM Administration:Topical administration, once (analgesia test) or daily for 7 consecutive days (irritation test)Result:Showed analgesic effect. A slight transepidermal water loss (TEWL) increased from 7.8 to 9.9 g/m2/h was observed.

——

Endocrinology/Hormones

5-HT Receptor

5-HT| Dopamine

——

——

32672-69-8

544.75

C27H32N2O4S3

>98% (HPLC)

DMSO: 10 mg/mL

OS(=O)(=O)C1=CC=CC=C1.CN1CCCCC1CCN1C2=CC=CC=C2SC2=C1C=C(C=C2)S(C)=O

——

(-20℃)

With Ice Pack

≥ 2 years