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首页- Products - Others - Other Targets - Succimer

Succimer

CAS No. 304-55-2

Succimer ( Succimer | DMSA )

产品货号. M13963 CAS No. 304-55-2

Succimer 是一种铅螯合剂。琥珀酸的作用机制是作为铅螯合活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
200MG ￥97 有现货
500MG ￥147 有现货
1G ￥203 有现货
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生物学信息

  • 产品名称
    Succimer
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    Succimer 是一种铅螯合剂。琥珀酸的作用机制是作为铅螯合活性。
  • 产品描述
    Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.(In Vivo):Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
  • 体外实验
    ——
  • 体内实验
    Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
  • 同义词
    Succimer | DMSA
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Cadmium| Lead| Mercury| Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    304-55-2
  • 分子量
    182.22
  • 分子式
    C4H6O4S2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 10 mM
  • SMILES
    O=C(O)[C@@H](S)[C@@H](S)C(O)=O
  • 化学全称
    meso-2,3-Dimercaptosuccinic acid;

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Blanusa M, et al. Curr Med Chem. 2005;12(23):2771-94.
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