P7C3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

P7C3 类神经保护性氨基丙基咔唑已被证明可以阻止神经变性模型中的神经元细胞死亡。

The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.

Western Blot Analysis Cell Line:BV2 cells Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:2 hours Result:Reduced the protein levels of iNOS, COX-2.

Animal Model:6-8 weeks male C57BL/6 mice (25-30 g)Dosage:20 mg/kg/d Administration:Intraperitoneal injection, twice daily, for 21 days Result:Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).

P7C3

Others

Other Targets

nicotinamide phosphoribosyltransferase

Neurological Disease

——

301353-96-8

474.19

C21H18Br2N2O

>98% (HPLC)

Soluble in DMSO

OC(CNC1=CC=CC=C1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol

(-20℃)

With Ice Pack

≥ 2 years