Guanfacine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种选择性 α2A 受体激动剂，可减少外周交感神经流出，从而降低外周交感神经张力。

A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone; a sympatholytic agent used to treat hypertension and attention deficit hyperactivity disorder (ADHD).Hypertension Approved.

Guanfacine increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level.Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks.

Guanfacine enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task.Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC.Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

Cardiovascular Disease

Hypertension

29110-47-2

246.0933

C9H9Cl2N3O

>98% (HPLC)

DMSO

C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl

Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-

(-20℃)

With Ice Pack

≥ 2 years