Mebeverine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

美贝维林是一种化合物，其主要治疗作用是治疗肠易激综合征（IBS）和相关的腹部绞痛。

Mebeverine is a drug whose major therapeutic role is in the treatment of irritable bowel syndrome (IBS) and the associated abdominal cramping. It works by relaxing the muscles in and around the gut. It is a musculotropic antispasmodic drug without anticholinergic side-effects. The drug is also indicated for treatment of gastrointestinal spasm secondary to organic disorder.(In Vitro):Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity.

Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity.

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Others

Other Targets

Others

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2753-45-9

466.01

C25H36ClNO5

>98% (HPLC)

DMSO: 10 mM

Cl.CCN(CCCCOC(=O)C1=CC(OC)=C(OC)C=C1)C(C)CC1=CC=C(OC)C=C1

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(-20℃)

With Ice Pack

≥ 2 years