Ipratropium Bromide ( Ipratropium Bromide )

产品货号. M13553 CAS No. 22254-24-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Ipratropium Bromide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Ipratropium Bromide 是 M3 型毒蕈碱乙酰胆碱受体的拮抗剂，用于治疗慢性阻塞性肺疾病 (COPD)。
产品描述

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
体外实验

Cell Viability Assay Cell Line:Adult Rat Cardiac Myocyte Concentration:0.001 nM-0.1 mM Incubation Time:2 h in dark; prior to 4 h hypoxia Result:Resulted cell viability in a dose-dependent manner, with the inhibition rate of 52.7% at 0.1 mM dose.
体内实验

Animal Model:Guinea-pigs of the Dunkin Hartley strain.Dosage:0.1-1 μg/kg Administration:Intravenous injection; single dose Result:Resulted little blocking effect on post-junctional muscarinic receptors at 0.3 μg/kg, and inhibited ACh-induced bronchoconstriction at 0.5 μg/kg.Animal Model:Male Sprague-Dawley rats (300-350 g) Dosage:0.04 mg/20 mL and 0.20 mg/20 mL Administration:Inhalation; atomization rate of 30 mL/30 min; 30 min Result:Had no significant effects on any parameters recorded in healthy rats but exerted a protective effect against the inflammatory reaction elicited by cadmium.
同义词

Ipratropium Bromide
通路

Endocrinology/Hormones
靶点

AChR
受体

M3 mAChR
研究领域

Neurological Disease
适应症

——

CAS Number

22254-24-6
分子量

412.37
分子式

C20H30BrNO3
纯度

>98% (HPLC)
溶解度

DMSO:83 mg/mL (201.27 mM); Ethanol:83 mg/mL (201.27 mM); Water:83 mg/mL (201.27 mM)
SMILES

CC([N+]1(C)C2CC(OC(C(C3=CC=CC=C3)CO)=O)CC1CC2)C.[Br-]
化学全称

(endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide

1. Zhang W, et al. Eur J Pharmacol,?010, 647(1-3), 178-187.

计算器

产品手册

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