GW-8510

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GW-8510 (GW8510) 是一种有效的、选择性的 CDK2 抑制剂，IC50 为 10 nM；体外生化检测显示对 CDK1 和 CDK4 具有弱抑制作用（IC50 分别为 110 和 130 nM）。

GW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays; only inhibits CDK5 on cultured neurons; downregulates the expression of XIAP and no detectable effect on the expression of Bax, Bak, or Bcl2; also demonstrates neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)).

Cell Viability AssayCell Line:HCT116 cells Concentration:0.5, 1, 2, 4 μM Incubation Time:72 hours Result:Inhibited HCT116 cells growth.Western Blot Analysis Cell Line:HCT116 cells Concentration:1, 2, 4 μM Incubation Time:24 hours Result:Inhibited RRM2 expression.The reduction of RRM2 protein level can be reversed by MG132.

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GW8510 | GW 8510

Angiogenesis

CDK

CDK

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222036-17-1

449.51

C21H15N5O3S2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (55.62 mM)

O=S(C1=CC=C(N/C=C2C(NC3=C\2C(SC=N4)=C4C=C3)=O)C=C1)(NC5=NC=CC=C5)=O

4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinylbenzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years