YKL 06-061

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YKL 06-061 是一种有效的、选择性的第二代盐诱导激酶 (SIK) 抑制剂，对 SIK1/2/3 的 IC50 分别为 6.56/1.77/20.5 nM。

YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively; inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases; dose-dependently increases MITF mRNA expression in human melanoma cells; induces significant pigmentation in Mc1r-deficient mice and normal human skin.

YKL 06-061 yields a dose-dependent increase in MITF mRNA expression. :RT-PC RCell Line:UACC62 human melanoma cells, and UACC257 human melanoma cells.Concentration:0-4 μM (UACC62); 0-16 μM (UACC257).Incubation Time:3 hours.Result:Yielded a dose-dependent increase in MITF mRNA expression.

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YKL06-061

Autophagy

SIK

SIK

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2172617-15-9

527.673

C30H37N7O2

>98% (HPLC)

DMSO : 62.5 mg/mL 118.45 mM; H2O : < 0.1 mg/mL

O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C

Pyrimido[4,5-d]pyrimidin-2(1H)-one,1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-

(-20℃)

With Ice Pack

≥ 2 years