NG-52

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NG 52 (Compound 52 ) 是一种有效的、细胞可渗透的、可逆的、选择性的、ATP 相容的细胞周期调节激酶抑制剂。

NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM).

Cell Proliferation Assay Cell Line:Glioma U87 and U251 cells Concentration:0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time:6 days Result:Potently inhibited the proliferation of primary glioma cells.Western Blot Analysis Cell Line:Glioma U87 and U251 cells Concentration:0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time:12 hours or 24 hours Result:Potently inhibited the proliferation of primary glioma cells.

Animal Model:Female nu/nu mice (5-week-old) injected with glioma cells Dosage:50 mg/kg, 100 mg/kg, 150 mg/kg Administration:Oral administration; daily; for 13 daysResult:Dose-dependently suppressed the growth of glioma xenograft.

Compound 52

Angiogenesis

CDK

Cdc28p

Cancer

——

212779-48-1

346.81

C16H19ClN6O

>98% (HPLC)

DMSO: > 100mM

CC(C)N1C2=NC(NCCO)=NC(NC3=CC=CC(Cl)=C3)=C2N=C1

2-((6-((3-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)ethan-1-ol

(-20℃)

With Ice Pack

≥ 2 years