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GSK 690
CAS No. 2101305-84-2
GSK 690 ( GSK690 )
产品货号. M13334 CAS No. 2101305-84-2
GSK 690 是一种不可逆的、基于机制的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，IC50 为 77 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4674 | 有现货 |
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| 10MG | ￥6774 | 有现货 |
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| 25MG | ￥9858 | 有现货 |
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| 50MG | ￥12834 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK 690
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GSK 690 是一种不可逆的、基于机制的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，IC50 为 77 uM。
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产品描述GSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
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体外实验GSK690 (1-10μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells).GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1?μM GSK690 for RD cells) and 10?μM GSK690 for RH30 cells.GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
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体内实验——
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同义词GSK690
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通路Chromatin/Epigenetic
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靶点Histone Demethylase
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受体Histone Demethylase
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研究领域——
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适应症——
化学信息
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CAS Number2101305-84-2
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分子量369.468
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分子式C24H23N3O
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纯度>98% (HPLC)
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溶解度——
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SMILESN#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1
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化学全称(R)-4-[5-(Pyrrolidin-3-ylmethoxy)-2-p-tolyl-pyridin-3-yl]-benzonitrile
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mould DP, et al. J Med Chem. 2017 Sep 11. doi: 10.1021/acs.jmedchem.7b00462.
2. Mould DP, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4755-4759.
3. McGrath JP, et al. Cancer Res. 2016 Apr 1;76(7):1975-88.
