Capzimin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Capzimin（Rpn11 抑制剂 3027）是 8TQ 的衍生物，是蛋白酶体异构肽酶 Rpn11 的有效且特异性抑制剂，IC50 为 0.34 uM。

Capzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 with IC50 of 0.34 uM, >7-fold improved potency over 8TQ (quinoline-8-thiol); shows >5-fold selectivity for Rpn11 over the related JAMM proteases and >2 logs less activity towards metalloenzymes (HDAC6, MMP2, MMP12, and carbonic anhydrase II); stabilizes proteasome substrates, induced an unfolded protein response, and blocks proliferation of cancer cells (HCT116 GI50=2.0 uM), including bortezomib-resistant retinal pigment epithelial cells.

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Rpn11 inhibitor 3027

Proteasome/Ubiquitin

Proteasome

Proteasome

Cancer

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2084867-65-0

315.409

C15H13N3OS2

>98% (HPLC)

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O=C(C1=CC2=CC=CC(S)=C2N=C1)NCCC3=NC=CS3

8-Mercapto-N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years