Nacubactam (b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nacubactam (OP 0595、RG 6080、RO 7079901) 是一种二氮杂双环辛烷，可抑制 A 类和 C 类 β-内酰胺酶，IC50 小于 1 uM。

Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo.Bacterial Infection Phase 1 Clinical.

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OP 0595 | RG 6080 | RO 7079901

GPCR/G Protein

Antibacterial

Antibacterial

Infection

Bacterial Infection

2007923-17-1

342.323

C9H18N4O8S

>98% (HPLC)

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C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)NOCCN.O

(2S, 5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, monohydrate

(-20℃)

With Ice Pack

≥ 2 years