021-51111890
购物车（）
sales@molnova.cn
MK-8353 hydrochloride
CAS No. 1951448-73-9
MK-8353 hydrochloride ( MK8353 )
产品货号. M13053 CAS No. 1951448-73-9
MK-8353 盐酸盐 (SCH-900353) 是一种高效、口服生物可利用的双特异性 ERK1/2 抑制剂，IC50 分别为 23.0/8.8 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称MK-8353 hydrochloride
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述MK-8353 盐酸盐 (SCH-900353) 是一种高效、口服生物可利用的双特异性 ERK1/2 抑制剂，IC50 分别为 23.0/8.8 nM。
-
产品描述MK-8353 hydrochloride (SCH-900353) is a highly potent, orally bioavailable, dual-specificity ERK1/2 inhibitor with IC50 of 23.0/8.8 nM, respectively; inhibits nonactivated ERK2 with IC50 of 0.5 nM, demonstrates excellent kinase selectivity over a 227-human kinase panel; decreases pERK1, pERK2, and ribosomal S6 kinase (pRSK) proteins, with complete suppression of pERK1 and pERK2 observed at 30 nM in A2058 cells, inhibits the in vitro proliferation of a panel of BRAFV600-mutant and RAS-mutant cancer cell lines; exhibits in vivo antitumor activity against BRAFV600 mutant Colo-205 colon cancer model and the BRAFV600 mutant SK-MEL-28 melanoma model.Colon Cancer Phase 1 Clinical.
-
体外实验——
-
体内实验——
-
同义词MK8353
-
通路MAPK/ERK Signaling
-
靶点ERK
-
受体ERK
-
研究领域Cancer
-
适应症Colon Cancer
化学信息
-
CAS Number1951448-73-9
-
分子量728.313
-
分子式C37H42ClN9O3S
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES——
-
化学全称(S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide hydrochloride
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Moschos SJ, et al. JCI Insight. 2018 Feb 22;3(4). pii: 92352.
