Cardamonin?

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

小豆蔻宁选择性阻断 TRPA1 激活 (IC50=454 nM)，同时不与 TRPV1 或 TRPV4 通道相互作用。

Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.

(E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.

(E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.

Alpinetin chalcone | Cardamomin

Chromatin/Epigenetic

COX

hTRPA1 cation channel

Other Indications

——

19309-14-9

270.28

C16H14O4

>98% (HPLC)

DMSO: 10 mM

O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2

2',4'-Dihydroxy-6'-methoxychalcone

(-20℃)

With Ice Pack

≥ 2 years