Ambroxol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ambroxol (NA-872) 是前体溴己辛的活性代谢产物，具有强效祛痰作用。Ambroxol 是一种葡糖脑苷脂酶 (GCase) 伴侣，可增加葡糖脑苷脂酶的活性。Ambroxol 可诱导肺自噬，并有用于帕金森氏病和神经性戈谢病研究的潜力。

Ambroxol is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.(In Vitro):Ambroxol (NA-872; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein.

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Ambroxol (NA-872; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein.

NA 872

Metabolic Enzyme/Protease

P450

CYP3A

Other Indications

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18683-91-5

378.1

C13H18Br2N2O

>98% (HPLC)

Soluble in DMSO

O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1

Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, trans- (9CI)

(-20℃)

With Ice Pack

≥ 2 years