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Tetrodotoxin citrate
CAS No. 18660-81-6
Tetrodotoxin citrate ( TTx citrate )
产品货号. M12881 CAS No. 18660-81-6
Tetrodotoxin (TTx) 是一种有效的、高选择性的钠通道阻滞剂，对于 Nav1.6 的 IC50 为 33 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tetrodotoxin citrate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tetrodotoxin (TTx) 是一种有效的、高选择性的钠通道阻滞剂，对于 Nav1.6 的 IC50 为 33 nM。
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产品描述Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6; Tetrodotoxin-sensitive sodium channel (Nav) family includes Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant; inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.Pain Phase 3 Clinical.
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体外实验——
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体内实验——
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同义词TTx citrate
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通路Membrane Transporter/Ion Channel
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靶点Sodium Channel
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受体Sodium Channel
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研究领域Neurological Disease
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适应症Pain
化学信息
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CAS Number18660-81-6
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分子量511.3915
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分子式C17H25N3O15
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纯度>98% (HPLC)
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溶解度H2O
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SMILESC(C(=O)O)C(CC(=O)O)(C(=O)O)O.C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O
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化学全称5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), [C(S),C(S),C(S),3S,4S,5R,9R,10R,11R]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rogers M, et al. Assay Drug Dev Technol. 2016 Mar;14(2):109-30.
2. Frelin C, et al. J Biol Chem. 1983 Jun 25;258(12):7256-9.
3. Reiser G, et al. Brain Res. 1983 Feb 21;261(2):335-40.
产品手册
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