Tofimilast

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tofimilast (CP-325366) 是一种有效的选择性 PDE4 抑制剂，对 PDE4A、PDE4B 和 PDE4D 的 IC50 分别为 23、13 和 13 nM。

Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively; shows weakly or no inhibition for PDE4C, and no activity for PDE1, PDE2, PDE3, PDE5, PDE6, and PDE7; increases cAMP levels in PGE1-stimulated U937 cells with an EC50 of 230 nM, inhibits human monocyte PDE mediated cAMP catabolism with an IC50 of 67 nM and LPS stimulated human monocyte TNFα release with an IC50 of 59 nM; shows low oral bioavailability and no emesis-associated behaviors in the ferret emesis model.Asthma Discontinued

——

——

CP-325366

Angiogenesis

PDE

PDE

Inflammation/Immunology

Asthma

185954-27-2

339.461

C18H21N5S

>98% (HPLC)

——

CCC1=NN(C2CCCC2)C3=C1CCN4C3=NN=C4C5=CC=CS5

9-Cyclopentyl-7-ethyl-3-(thiophen-2-yl)-6,9-dihydro-5H-pyrazolo(3,4-c)-1,2,4-triazolo(4,3-a)pyridine

(-20℃)

With Ice Pack

≥ 2 years