AZD-0156

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZD-0156 (AZD0156, AZD 0156) 是一种有效的、高选择性的、口服生物可利用的 ATM 抑制剂；表现出抗肿瘤活性，既可以减轻肿瘤负荷，又可以防止肿瘤在具有免疫功能的 AML 同种异体移植小鼠模型中生长。

AZD-0156 (AZD0156, AZD 0156)?is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors Phase 1 Clinical(In Vitro):AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.

AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.

——

AZD0156 | AZD 0156

Cell Cycle/DNA Damage

ATM/ATR

ATM

Cancer

Solid Tumors

1821428-35-6

461.556

C26H31N5O3

>98% (HPLC)

DMSO: 6.2 mg/mL (Need ultrasonic and warming)

O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3

2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-

(-20℃)

With Ice Pack

≥ 2 years