QcrB inhibitor TB47 ( TB47 )

产品货号. M12724 CAS No. 1799682-71-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

QcrB inhibitor TB47
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

QcrB 抑制剂 TB47 (TB47) 是一种新型抗分枝杆菌化合物，作为假定的呼吸复合物 III (QcrB) 抑制剂，针对 56 M 组的 MIC 为 0.016-0.5 ug/mL。
产品描述

QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates; shows promising profiles, including negligible CYP450 interactions, cytotoxicity and hERG channel inhibition in pharmacokinetic and toxicity studies; causes metabolic redox stress, strongly synergistic with pyrazinamide and rifampicin in mouse infection models, but not as a monotherapy.
体外实验

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体内实验

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同义词

TB47
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

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适应症

——

CAS Number

1799682-71-5
分子量

538.571
分子式

C29H29F3N4O3
纯度

>98% (HPLC)
溶解度

——
SMILES

CC1=NN2C=CC(=CC2=C1C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F)OC
化学全称

5-methoxy-2-methyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)pyrazolo[1,5-a]pyridine-3-carboxamide

1. Lu X, et al. ACS Infect Dis. 2018 Nov 28. doi: 10.1021/acsinfecdis.8b00225.

计算器

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