Valganciclovir hydrochloride ( Ro 107-9070/194 | Valcyte )

产品货号. M12657 CAS No. 175865-59-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Valganciclovir hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

缬更昔洛韦（盐酸盐）是更昔洛韦的L-缬氨酰酯，实际上是更昔洛韦的前药。
产品描述

Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.
体外实验

Cell Viability Assay Cell Line:A549 cells Concentration:500 μM Incubation Time:5 days, 7days Result:Showed EC50 values ranged from 120.5 μM (Ad4) to 244.4 μM (Ad6).Showed IC50 values was calculated to be 11.74 mM at 7 days post-infection.
体内实验

Animal Model:Immunosuppressed hamstersDosage:200 mg/kg Administration:Oral gavage (p.o.)Result:Resulted in significantly smaller magnitude of weight loss for all groups.Reduced the liver pathology.
同义词

Ro 107-9070/194 | Valcyte
通路

Others
靶点

Other Targets
受体

CMV
研究领域

Infection
适应症

——

CAS Number

175865-59-5
分子量

390.82
分子式

C14H23ClN6O5
纯度

>98% (HPLC)
溶解度

Water: 78 mg/mL (199.58 mM); DMSO: 78 mg/mL (199.58 mM)
SMILES

CC(C)[C@H](N)C(OCC(OCN1C=NC2=C1NC(N)=NC2=O)CO)=O.[H]Cl
化学全称

[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate hydrochloride

1.Sugawara M, et al. J Pharm Sci, 2000, 89(6), 781-789.

计算器

产品手册

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