ARS-1630 ( ARS1630 | ARS1620 R-atropisomer )

产品货号. M12592 CAS No. 1698055-86-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ARS-1630
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ARS-1630 是 ARS-1620 的 R 构象阻转异构体。
产品描述

ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.
体外实验

KRASG12C is recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP is restricted only to the GDP-bound state. This strategy proves feasible for inhibiting mutant KRAS in vitro.
体内实验

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同义词

ARS1630 | ARS1620 R-atropisomer
通路

MAPK/ERK Signaling
靶点

Ras
受体

Ras
研究领域

Cancer
适应症

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CAS Number

1698055-86-5
分子量

430.84
分子式

C21H17ClF2N4O2
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 69 mg/mL 160.15 mM
SMILES

C=CC(N1CCN(C2=C3C=C(Cl)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[R]
化学全称

(R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

1. Janes MR, et al. Cell. 2018 Jan 25;172(3):578-589.e17.

计算器

产品手册

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