PD98059

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PD98059 (PD 098059) 是一种特异性 MEK 抑制剂，IC50 约为 10 uM，对 MAPK 没有显着的抑制活性。

PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK; prevents activation of MAPK and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells.(In Vitro):PD98059 (20 μM; 24 hours) causes G1-phase cell cycle arrest in OCI-AML-3 cells.PD98059 (10 μM; 22 hours) results in concentration-dependent reductions in the dually phosphorylated forms of ERK1 and ERK2. PD98059 both prevents ERK activation and blocks formation of TDP-43 and HuR-positive SGs.(In Vivo):PD98059 (10 mg/kg; i.p.; 1 and 6 hours after Zymosan) significantly reduces the level of p-ERK1/2 in zymosan-injected mice.

Cell Cycle Analysis Cell Line:OCI-AML-3 cells Concentration:20 μM Incubation Time:24 hours Result:Caused G1-phase cell cycle arrest.Western Blot Analysis Cell Line:MCF10A-Neo, MCF10ANeoT cells Concentration:10 μM Incubation Time:22 hours Result:Phosphorylated ERK forms were almost completely eliminated in both cell lines.

Animal Model:Male CD miceDosage:10 mg/kgAdministration:Intraperitoneal injection; 1 and 6 hours after ZymosanResult:Significantly reduced the level of p-ERK1/2.

PD 098059 | PD-98059

MAPK/ERK Signaling

MEK

MEK1

Cancer

——

167869-21-8

267.2793

C16H13NO3

>98% (HPLC)

DMSO: 16 mg/mL; H2O: < 0.01 mg/mL

O=C1C=C(C2=CC=CC(OC)=C2N)OC3=C1C=CC=C3

4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)-

(-20℃)

With Ice Pack

≥ 2 years