JAS239 ( JAS 239 | JAS-239 )

产品货号. M12448 CAS No. 1630288-74-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

JAS239
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JAS239 是一种新型碳花青染料，可在细胞内结合并竞争性抑制胆碱激酶 (ChoK)。
产品描述

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines; inhibits the phosphorylation of 14C-labeled choline in MDA-MB-231 triple-negative breast cancer cells with IC50 of 4.6 uM, significant reduces MDA-MB-231 viability with IC50 of 13.3 uM; a NIR-fluorescent ChoK inhibitor.
体外实验

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体内实验

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同义词

JAS 239 | JAS-239
通路

Others
靶点

ChoK
受体

ChoK
研究领域

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适应症

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CAS Number

1630288-74-2
分子量

505.099
分子式

C31H37ClN2O2
纯度

>98% (HPLC)
溶解度

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SMILES

CC1(C)C(/C=C/C=C/C=C/C=C2N(CCO)C3=C(C=CC=C3)C/2(C)C)=[N+](CCO)C4=C1C=CC=C4.[Cl-]
化学全称

1-(2-hydroxyethyl)-2-((1E,3E,5E)-7-((Z/E)-1-(2-hydroxyethyl)-3,3-dimethylindolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-3H-indol-1-ium chloride