GSK-467

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSK-467 是一种有效的选择性 KDM5 抑制剂，Ki 为 10 nM。

GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members; increases the rate of apoptosis in myeloma cells.

Cell Proliferation Assay Cell Line:Human multiple myeloma tumor cell line MM.1S Concentration:0-100 μM Incubation Time:6 days Result:Showed antiproliferative effect with an IC50 of >50 μM.

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GSK467

Chromatin/Epigenetic

Histone Demethylase

Histone Demethylase

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1628332-52-4

319.32

C17H13N5O2

>98% (HPLC)

DMSO : 20.83 mg/mL 65.23 mM; H2O : < 0.1 mg/mL

O=C1C2=C(C=NC=C2)N=C(OC3=CN(CC4=CC=CC=C4)N=C3)N1

2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one

(-20℃)

With Ice Pack

≥ 2 years