Tesirine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tesirine ( SG3249) 是一种组织蛋白酶 B 可裂解的缬氨酸-丙氨酸吡咯并苯二氮卓 (PBD) 二聚体，作为抗体药物偶联物 (ADC) 有效负载。

Tesirine ( SG3249) is a cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine (PBD) dimer as antibody-drug conjugate (ADC) payload; Tesirine (SG3249) was designed to combine potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics; Rovalpituzumab tesirine is a first-in-class antibody-drug conjugate directed against delta-like protein 3 (DLL3), a novel target identified in tumour-initiating cells and expressed in small-cell lung cancer.

Tesirine (SG3199) is the released warhead component of the ADC payload Tesirine. Tesirine inhibits K562, NCIN87, BT474, and SKBR3 cancer cells with IC50s of 150 pM, 20 pM, 1 nM and 320 pM.

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SG3249 | SG-3249

Antibody Drug Conjugates (ADC)

Drug-Linker Conjugates

Drug-Linker Conjugates

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1595275-62-9

1496.673

C75H101N9O23

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (133.63 mM)

CC1=CN2C(C1)C=NC3=CC(=C(C=C3C2=O)OC)OCCCCCOC4=C(C=C5C(=C4)N(C(C6CC(=CN6C5=O)C)O)C(=O)OCC7=CC=C(C=C7)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN8C(=O)C=CC8=O)OC

4-((S)-N-((S)-1-amino-1-oxopropan-2-yl)-34-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-isopropyl-4,32-dioxo-7,10,13,16,19,22,25,28-octaoxa-3,31-diazatetratriacontanamido)benzyl (11S,11aS)-11-hydroxy-7-methoxy-8-((5-(((S)-7-methoxy-2-methyl-5-oxo-5,11a-dihydr

(-20℃)

With Ice Pack

≥ 2 years