Serotonin hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-羟色胺盐酸盐是一种单胺神经递质和内源性 5-HT 受体激动剂。

Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.(In Vitro):Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki=?44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT.(In Vivo):Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis.

Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki=?44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT.

Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis.

5-HT | 5-Hydroxytryptamine

Endocrinology/Hormones

5-HT Receptor

5-HT

Neurological Disease

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153-98-0

212.68

C10H12N2O·HCl

>98% (HPLC)

Ethanol: 2 mg/mL (9.4 mM); Water: 43 mg/mL (202.18 mM); DMSO: 43 mg/mL (202.18 mM)

Cl.NCCC1=CNC2=C1C=C(O)C=C2

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(-20℃)

With Ice Pack

≥ 2 years