NS 1619

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

据报道，NS1619 在缺血再灌注损伤后具有心脏保护作用。

NS1619 have been reported to have cardio-protective effects after ischemic-reperfusion injury.

NS1619 (5, 10, 30, 50, and 100 μM) inhibits the proliferation of A2780 cells in a dosage and time dependent manner IC50=31.1 μM for 48 h pretreatment.NS1619 (30 μM) exhibits augmenting effect on whole cell IK in human ovarian cancer cells A2780.NS1619 (10, 30, 50, and 100 μM) increases levels of p53, p21Cip1 and Bax proteins in A2780 cells.DNA content of A2780 cells was significantly decreased after 36 and 48 h of pretreatment. The breakdown of DNA results in death of the tumor cells. Cell Viability AssayCell Line:The human ovarian cancer cell line A2780 Concentration:5, 10, 30, 50, and 100 μM Incubation Time:48 hours Result:Inhibited cell growth in a time and concentration-dependent manner, IC50=31.1 μM. Proliferation was significantly inhibited at concentrations of NS1619 higher than 10 μM. Western Blot Analysis Cell Line:A2780 cells Concentration:0, 5, 10, 30, 50, and 100 μM Incubation Time:48 hours Result:Expression of p53, p21, and Bax in A2780 cells was significantly increased in comparison with control.Western Blot Analysis Cell Line:A2780 cells Concentration:30 μM Incubation Time:36 and 48 hours Result:DNA content of A2780 cells was significantly decreased after 36 and 48 h of pretreatment. The breakdown of DNA results in death of the tumor cells.

Opening of KCa channels with NS-1619 (1 mg/kg; i.p.) can delay protection in mouse hearts. Animal Model:Adult male outbred ICR mice Dosage:1 mg/kg Administration:Pretreated i.p. 24 h before I/R Result:Pretreatment induced delayed protection 24 h later.Resulted in significant cardioprotection 24 h later, i.e., infarct size was reduced from 38.8 ± 3.7% to 19.8 ± 2.9%.

NS1619 | NS-1619 | NS 1619.

Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

Cardiovascular Disease

——

153587-01-0

362.23

C15H8F6N2O2

>98% (HPLC)

DMSO: > 10 mM

O=C1NC2=CC(C(F)(F)F)=CC=C2N1C3=CC(C(F)(F)F)=CC=C3O

1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

(-20℃)

With Ice Pack

≥ 2 years