Edetate?Trisodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

乙二胺四乙酸 (EDTA) 三钠盐在螯合疗法实践中用于结合金属离子，用于治疗汞和铅中毒。

Ethylenediaminetetraacetic acid (EDTA) trisodium salt is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.

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Animal Model:Male Wistar rat model of cirrhosis induced by CCl4Dosage:60 mg/kg, 120 mg/kg, 240 mg/kg Administration:Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).Result:Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.Reduced fibrosis of the liver in surviving rats (20%).Animal Model:Male Wistar rat model of cirrhosis induced by CCl Dosage: 60 mg/kg Administration:Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).Result:Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group).Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.

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Others

Other Targets

metal ion

Other Indications

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150-38-9

358.19

C10H13N2Na3O8

>98% (HPLC)

Soluble in Water

O.O.[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years