Clemastine fumarate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Clemastine Fumarate 是一种选择性组胺 H1 受体拮抗剂，IC50 为 3 nM。

Clemastine Fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM. (In Vitro):Vorinostat efficiently suppresses MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. HDACs class I (HDAC2 and 3) as well as class II (HDAC7) are preferentially affected by this treatment. Vorinostat significantly increases p21WAF1 expression and apoptosis in MES-SA cells.Vorinostat inhibits SK-N-SH and SK-N-Be(2)C with the IC25 values of 1 μM and 0.5 μM, respectively.Vorinostat is an effective inhibitor of HPV-18 DNA amplification, reduces oncoproteins E6 and E7 activities and triggers apoptosis in HPV-infected, differentiated cells.

——

——

——

GPCR/G Protein

Histamine Receptor

H1 receptor

Neurological Disease

——

14976-57-9

459.97

C25H30ClNO5

>98% (HPLC)

DMSO: 35 mg/mL warmed (76.09 mM)

C[C@@](C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCC[C@H]3CCCN3C.C(=C/C(=O)O)\C(=O)O

——

(-20℃)

With Ice Pack

≥ 2 years