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BI 1467335
CAS No. 1478364-68-9
BI 1467335 ( PXS-4728A | PXS-4728 )
产品货号. M12040 CAS No. 1478364-68-9
BI 1467335 (PXS-4728A, PXS-4728) 是一种有效的、选择性的、口服活性的 SSAO/VAP-1 (AOC3) 抑制剂，IC50 为 5 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥530 | 有现货 |
|
| 5MG | ￥852 | 有现货 |
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| 10MG | ￥1501 | 有现货 |
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| 25MG | ￥3134 | 有现货 |
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| 50MG | ￥4538 | 有现货 |
|
| 100MG | ￥6291 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥945 | 有现货 |
|
生物学信息
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产品名称BI 1467335
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BI 1467335 (PXS-4728A, PXS-4728) 是一种有效的、选择性的、口服活性的 SSAO/VAP-1 (AOC3) 抑制剂，IC50 为 5 nM。
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产品描述BI 1467335 (PXS-4728A,?PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.Steatohepatitis,Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词PXS-4728A | PXS-4728
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Other Indications
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适应症Steatohepatitis
化学信息
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CAS Number1478364-68-9
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分子量316.8
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分子式C15H21FN2O2.HCl
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (789.14 mM)
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SMILESCC(C)(C)NC(=O)C1=CC=C(C=C1)OCC(=CF)CN.Cl
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化学全称(E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Schilter HC, et al. Respir Res. 2015 Mar 20;16:42.
2. Jarnicki AG, et al. Br J Pharmacol. 2016 Nov;173(22):3161-3175.
3. Katagiri D, et al. Respir Res. 2015 Mar 20;16:42.
产品手册
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