JG-231 是一种变构抑制剂，可破坏 Hsp70-BAG3 相互作用 (Ki=0.11 uM)。

A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus of hsc70-interacting protein (CHIP), TPR1 and human glutamine-rich TPR-containing protein (hSGT), on refolding of luciferase by DnaJ and hsc70 was investigated.

YM-1 是 MTK-077 的紧密衍生物，以变构方式促进 Hsp70 与未折叠底物的结合，与 Hsp70 特异性结合，Kd 为 4.9 uM。