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APTO-253 isomer
CAS No. 1422826-80-9
APTO-253 isomer ( APTO253 | LOR253 | LOR-253 )
产品货号. M11778 CAS No. 1422826-80-9
APTO-253 是 KLF4 的小分子诱导剂，可稳定 G-四链体 DNA 并降低 MYC mRNA 表达和蛋白质水平。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥9858 | 有现货 |
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| 50MG | ￥12834 | 有现货 |
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| 100MG | ￥15750 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称APTO-253 isomer
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述APTO-253 是 KLF4 的小分子诱导剂，可稳定 G-四链体 DNA 并降低 MYC mRNA 表达和蛋白质水平。
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产品描述APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels; APTO-253 is converted intracellularly from a monomer to a ferrous complex [Fe(253)3]; selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans, induces DNA Damage in AML cells.Blood Cancer Phase 1 Clinical.
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体外实验——
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体内实验——
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同义词APTO253 | LOR253 | LOR-253
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通路Cell Cycle/DNA Damage
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靶点c-Myc
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受体c-Myc
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number1422826-80-9
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分子量367.387
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分子式C22H14FN5
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(N1)=C(C2=NC3=C4C=CC=NC4=C5N=CC=CC5=C3N2)C6=C1C=C(F)C=C6
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化学全称2-(6-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Tsai CY, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-0834.
2. Cercek A, et al. Invest New Drugs. 2015 Oct;33(5):1086-92.
3. Wang B, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492.
4. Local A, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-1209.
