Alvimopan monohydrate ( Alvimopan monohydrate )

产品货号. M11587 CAS No. 1383577-62-5

一种选择性外周作用 μ-阿片类拮抗剂，IC50 为 1.7 nM，用于治疗术后肠梗阻。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
50MG	￥3897	有现货
100MG	￥5733	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Alvimopan monohydrate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种选择性外周作用 μ-阿片类拮抗剂，IC50 为 1.7 nM，用于治疗术后肠梗阻。
产品描述

A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.Other Indication Approved.
体外实验

Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM.
体内实验

Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
同义词

Alvimopan monohydrate
通路

Endocrinology/Hormones
靶点

Opioid Receptor
受体

Opioid Receptor
研究领域

Other Indications
适应症

Other Disease

化学信息

CAS Number

1383577-62-5
分子量

442.5479
分子式

C25H34N2O5
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

C[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)Cc2ccccc2)CC[C@]1(c3cc(O)ccc3)C.O
化学全称

Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:1)

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70. 2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40. 3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.

计算器

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摩尔计算器

分子量计算器

产品手册

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