Macozinone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Macozinone (PBTZ-169, PBTZ169) 是一种有效的第二代抗结核化合物，可抑制 DprE1，并在体外对结核分枝杆菌表现出纳摩尔级杀菌活性。

Macozinone (PBTZ-169, PBTZ169)?is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.Bacterial Infection Phase 2 Clinical(In Vitro):Macozinone (PBTZ169) is highly potent against M. tuberculosis in vitro, ex vivo, and in vivo.

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PBTZ169 | PBTZ-169

GPCR/G Protein

Antibacterial

DprE1

Infection

Bacterial Infection

1377239-83-2

456.484

C20H23F3N4O3S

>98% (HPLC)

DMSO: 6.4 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14

2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

(-20℃)

With Ice Pack

≥ 2 years