Xylocaine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

利多卡因是一种酰胺局部麻醉剂，在体外和体内都具有抗炎特性，这可能是由于促炎细胞因子的减弱所致。

Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.(In Vitro):Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation.Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10?nM and treatment time 48?hours.Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate.Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly.(In Vivo):Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block.

——

Lidocaine GMP (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by Lidocaine GMP has slower onset and faster recovery compared with thermal nociception block.

NSC 40030

GPCR/G Protein

Histamine Receptor

H1 receptor

Cardiovascular Disease

——

137-58-6

234.34

C14H22N2O

>98% (HPLC)

Ethanol: 47 mg/mL (200.56 mM); Water: 9 mg/mL (38.4 mM); DMSO: 47 mg/mL (200.56 mM)

O=C(NC1=C(C)C=CC=C1C)CN(CC)CC

2',6'-Acetoxylidide, 2-(diethylamino)-

(-20℃)

With Ice Pack

≥ 2 years