P516-0475 ( P516-0475 | P5160475 | P516 0475 )

产品货号. M11475 CAS No. 1359627-33-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

P516-0475
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

P516-0475 是一种新型链球菌群体感应化学诱导剂，通过抑制信息素降解内肽酶 PepO 发挥作用（IC50=10 uM）。
产品描述

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM); specifically induces expression of Rgg2/3-regulated genes in the presence of SHP pheromones at concentrations lower than typically required for QS induction; P516-0475 directly inhibits recombinant PepO in vitro as an uncompetitive inhibitor, induces QS by stabilizing SHP pheromones in culture.
体外实验

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体内实验

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同义词

P516-0475 | P5160475 | P516 0475
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

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适应症

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CAS Number

1359627-33-0
分子量

315.333
分子式

C15H17N5O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=C2N(N=N1)C3=C(C=C(C)C=C3)NC2=O)NCCCOC
化学全称

N-(3-methoxypropyl)-7-methyl-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]quinoxaline-3-carboxamide

1. Pérez Morales TG, et al. J Biol Chem. 2018 Jan 19;293(3):931-940.

计算器

产品手册

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