Arylsulfonamide 64B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Arylsulfonamide 64B（HIF 抑制剂 64B）是一种小分子 HIF 通路抑制剂。

Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule HIF pathway inhibitor, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration; blocks HIF-1α association with co-factors p300 and CBP at low micromolar concentrations, disrupts the HIF transcription complex by interfering with HIF-1α recruitment of p300/CBP co-factors on hypoxia-responsive elements on target genes; demonstrates strong anti-cancer activity in syngeneic and xenogeneic orthotopic UM mouse models, Arylsulfonamide 64B (64B) is a potent inhibitor of the hypoxiainduced CXCR4 and c-Met-mediated signaling axis that controls in vitro tumor cell motility; shows potent anti-tumor activity at the primary melanoma growth site in the eye, reduces circulating tumor cells, and strongly inhibits spontaneous formation and expansion of metastases in the liver with minimal toxicity.

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HIF inhibitor 64B

Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF/HIF Prolyl-hydroxylase

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1342890-83-8

444.546

C23H28N2O5S

>98% (HPLC)

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CC1(C=CC2=C(O1)C=CC(=N2)CN(C3CCC3)S(=O)(=O)C4=CC(=C(C=C4)OC)OC)C

N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years