Go 6983

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Go 6983 是一种针对 PKCα、PKCβ、PKCγ 和 PKCδ 的泛 PKC 抑制剂，IC50 分别为 7 nM、7 nM、6 nM 和 10 nM。

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.(In Vitro):Go 6983 inhibits PKCμ with IC50 of 20 μM, and the pther PKC isoenzymes can be suppressed by Go 6983 with IC50 values from 7 to 60 nM. Go 6983 (100 nM) significantly reduces PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts, and significantly inhibits superoxide release from PMNs by 90 +/- 2% in rat hearts. Go 6983 (200 nM) has a reduced cardioprotective effect compared with the cardioprotective Go 6983 concentrations (50 and 100 nM) despite inhibiting PMN superoxide release by 99%.

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Go6983 Go-6983 | Go 6983

Angiogenesis

PKC

PKCα| PKCβ| PKCγ| PKCδ| PKCζ

Cancer

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133053-19-7

442.51

C26H26N4O3

>98% (HPLC)

DMSO: 59 mg/mL (133.33 mM)

O=C(C(C1=CN(CCCN(C)C)C2=C1C=C(OC)C=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O

3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

(-20℃)

With Ice Pack

≥ 2 years