Diphenylpyraline hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Diphenpyraline Hcl 是第一代抗组胺药，具有抗胆碱能作用，可作为多巴胺再摄取抑制剂。

Diphenylpyraline Hcl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor, shows to be useful in the treatment of Parkinsonism.(In Vitro):Diphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices.(In Vivo):Diphenylpyraline hydrochloride (intraperitoneal injection; 5-10 mg/kg) elevates extracellular dopamine levels (~200%) in mouse nucleus accumbens and induces locomotor activation in mice.

Diphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices.

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Diphenylpyraline hydrochloride | Diafen hydrochloride | Diaphen

GPCR/G Protein

Histamine Receptor

H1 receptor

Neurological Disease

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132-18-3

317.85

C19H23NO·HCl

>98% (HPLC)

Soluble in DMSO

CN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1.[H]Cl

Piperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride

(-20℃)

With Ice Pack

≥ 2 years