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Diphenylpyraline hydrochloride
CAS No. 132-18-3
Diphenylpyraline hydrochloride ( Diphenylpyraline hydrochloride | Diafen hydrochloride | Diaphen )
产品货号. M11298 CAS No. 132-18-3
Diphenpyraline Hcl 是第一代抗组胺药，具有抗胆碱能作用，可作为多巴胺再摄取抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | ￥111 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥238 | 有现货 |
|
生物学信息
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产品名称Diphenylpyraline hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Diphenpyraline Hcl 是第一代抗组胺药，具有抗胆碱能作用，可作为多巴胺再摄取抑制剂。
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产品描述Diphenylpyraline Hcl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor, shows to be useful in the treatment of Parkinsonism.(In Vitro):Diphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices.(In Vivo):Diphenylpyraline hydrochloride (intraperitoneal injection; 5-10 mg/kg) elevates extracellular dopamine levels (~200%) in mouse nucleus accumbens and induces locomotor activation in mice.
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体外实验Diphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices.
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体内实验——
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同义词Diphenylpyraline hydrochloride | Diafen hydrochloride | Diaphen
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通路GPCR/G Protein
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靶点Histamine Receptor
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受体H1 receptor
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number132-18-3
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分子量317.85
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分子式C19H23NO·HCl
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纯度>98% (HPLC)
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溶解度Soluble in DMSO
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SMILESCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1.[H]Cl
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化学全称Piperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lapa GB, et al. Eur J Pharmacol. 2005, 506(3):237-40.
