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TNP-470
CAS No. 129298-91-5
TNP-470 ( TNP470 | AGM-1470 | AGM1470 )
产品货号. M11185 CAS No. 129298-91-5
TNP-470 (AGM-1470) 是一种特异性、可逆的 MetAP-2 抑制剂和抗血管生成化合物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2185 | 有现货 |
|
| 10MG | ￥4076 | 有现货 |
|
| 25MG | ￥9179 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TNP-470
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TNP-470 (AGM-1470) 是一种特异性、可逆的 MetAP-2 抑制剂和抗血管生成化合物。
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产品描述TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis; has anti-growth factor properties and inhibits the activation of Cdk 2 and phosphorylation of RB protein, inhibits potently PDGF- and bFGF-stimulated proliferation of rat mesangial cells in vitro (IC50 = 50 pg/ml); inhibits tumor growth and metastasis of rodent tumors; does not bind to or inhibit MetAP-1.Blood CancerPhase 1 Discontinued.
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体外实验——
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体内实验——
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同义词TNP470 | AGM-1470 | AGM1470
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通路Metabolic Enzyme/Protease
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靶点Aminopeptidase
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受体Aminopeptidase
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number129298-91-5
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分子量401.884
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分子式C19H28ClNO6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (248.83 mM)
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SMILESO=C(NC(CCl)=O)O[C@@H]1CC[C@@]2(OC2)[C@]([C@](O3)(C)[C@H]3C/C=C(C)/C)([H])[C@@H]1OC
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化学全称Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester (9CI)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yamaoka M, et al. Cancer Res. 1993 Sep 15;53(18):4262-7.
2. Haraguchi M, et al. Kidney Int. 1997 Jun;51(6):1838-46.
3. Garrabrant T, et al. Angiogenesis. 2004;7(2):91-6.
4. Ingber D, et al. Nature. 1990 Dec 6;348(6301):555-7.
